Basic and Clinical NeurocardiologyJ. Andrew Armour, Jeffrey L. Ardell Oxford University Press, 2004 M05 6 - 480 páginas The progression of heart disease is associated with changes in the neurohumoral mechanisms that control cardiac function. The degree to which this neurohumoral remodeling occurs, even before overt signs of cardiac disease become manifest, is important for prognosis. To determine why some patients experience sudden death while others sustain life in the presence of severely compromised cardiac function, the neuronal control of cardiac electrical and mechanical events must be considered. Starting at the level of individual neurons and building upwards, this book describes the synergistic interactions that occur among intrathoracic and CNS feedback loops to permit precise control of regional cardiac behavior. On this basic science foundation, subsequent clinical chapters explore the remodeling that occurs in this system with aging, with the evolution of specific cardiac pathologies, and with the psychological concomitants of heart disease. Most importantly, these chapters provide unique insights into how specific therapies like beta-andrenergic receptor blockade not only affect cardiomyocytes directly but also mitigate the adverse neurohumoral changes that accompany disease processes, such as heart failure and essential hypertension. The paradigm advanced in this volume is that heart disease is a multifaceted phenomenon involving the interplay of neurohumoral, cardiomyocyte and structural elements, each of which depends on the other. With our cumulative understanding of these interdependent processes, new avenues for time-appropriate, targeted methods of treating heart diseases can be developed. |
Contenido
1 | |
Contributors | 44 |
Colocalization of Multiple Neurochemicals in Mammalian | 61 |
Cardiac Sensory Neurons | 79 |
Intrathoracic Neuronal Regulation of Cardiac Function | 118 |
Integrative Control of Cardiac Function by Cervical and Thoracic | 153 |
Central Nervous System Regulation of the Heart | 187 |
School of Biomedical Sciences Decorah Iowa | 217 |
Aging and Neural Responses in the Heart | 272 |
The Genesis of Pain during Myocardial Ischemia and Infarction | 298 |
Neuronal Modulation of Atrial and Ventricular | 315 |
Sympathetic Nervous System in the Evolution of Heart Failure | 340 |
The Pathogenesis of Hypertension | 368 |
Psychological Aspects of Heart Disease | 393 |
Relevance of the Cardiac Neuronal Hierarchy | 419 |
Saint Margaret Mercy Healthcare M D | 420 |
Forebrain Control of Healthy and Diseased Hearts | 220 |
Ontogeny of the Cardiac Nervous System | 252 |
Department of Pharmacology College of Medicine | |
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action potentials adenosine adenylyl cyclase adrenergic afferent neurons angina pectoris angiotensin aortic Ardell JL Armour arterial pressure associated Auton autonomic axons baroreceptor baroreflex blood pressure bradykinin Brain Res Ca2+ canine cardiac afferent neurons cardiac function cardiac nervous system cardiac vagal Cardiol cardiomyocytes cardiovascular catecholamines cells central Circ Res Circulation Comp Neurol contractile coronary artery diac dorsal effects electrical Foreman RD Gootman guinea pig heart disease heart failure hypertension increased induced inhibition innervation inputs insular cortex intracardiac neurons intrathoracic intrinsic cardiac nervous intrinsic cardiac neurons ischemic mechanisms mechanosensory mediated modulation muscarinic myocardial infarction myocardial ischemia myocardium myocytes neonatal neural neuronal activity neuropeptide Neurosci nicotinic norepinephrine nucleus pain parasympathetic parasympathetic efferent pathways patients peptide peripheral Pharmacol Physiol postganglionic preganglionic rat intracardiac receptors reflex regional release responses role sensory neurites sinus somata spinal cord stimulation stress studies sympathetic efferent sympathetic nervous system synaptic thoracic tion transduction vagal efferent ventricular
Referencias a este libro
Being a Brain Wise Therapist: A Practical Guide To Interpersonal Neurobiology Bonnie Badenoch Vista previa limitada - 2008 |