Life Saving Drugs: The Elusive Magic BulletRoyal Society of Chemistry, 2004 - 248 páginas In 1900 only a handful of drugs (morphine, quinine, aspirin etc) had genuine efficacy and recovery from infections was haphazard. Now there are literally thousands of drugs and life-threatening infections have been either overcome or much diminished. Life-saving Drugs: the Elusive Magic Bullet describes the discovery and development of antibacterial, anti-viral and anti-cancer drugs. The book highlights the colourful characters behind the inventions and the huge improvements in quality of life and life-expectancy that these drugs have produced. Emphasis is given to the new drugs that have emerged as a result of knowledge of the human genome, and the ways in which the newer drugs are being designed to tackle disease, particularly cancer, at the genetic level. Chemical structures are provided for all of the key drugs and the book is well illustrated. Life-saving Drugs: the Elusive Magic Bullet can be read as a history of drug development during the past 100 years by those with only a passing knowledge of chemistry. For anyone entering the medical profession, pharmacy, or nursing, it will provide a superb basic knowledge of all drugs they are ever likely to meet, including their modes of action. For the chemist or medicinal chemist, it will provide the fundamental knowledge of life-saving drugs that they all should know. And for the non-scientist who wants to know about 'super-bugs', SARS, Ebola, and all of the wonderful advances in treating cancer, it is illuminating and easy to read. |
Contenido
Chapter | 1 |
Fighting Bacteria | 11 |
Antiseptics | 18 |
The First Antibacterials | 27 |
Early Ideas of Antibiosis | 33 |
Chain and Florey and the Penicillin Production Line | 42 |
SemiSynthetic Penicillins and the Growing Problem of Resistance | 48 |
The Mode of Action of the Penicillins and Cephalosporins | 56 |
Chapter 3 | 85 |
Coughs and Colds and Influenza | 105 |
Chapter 4 | 141 |
Cancer Chemotherapy | 156 |
AntiCancer | 175 |
Microorganisms also Produce AntiTumour Agents | 189 |
Biological Warfare Against Cancer Cells | 211 |
Further Reading | 233 |
Términos y frases comunes
acid agents analogues anastrozole animal anti-cancer anti-tumour antibacterial antibiotics bacillus bacteria bacterium became beta-lactam breast cancer cancer cells CARBOLIC SMOKE caused cell membrane cephalosporin CH3 CH3 CH3 H Chem chemical chemotherapy clinical trials CO₂H compounds cowpox culture cure death discovery disease drug effects Ehrlich enzymes epidemic especially extract fever Fleming genes genetic glycoprotein growth H₂N hormone Hospital host cell human immune system infection influenza inhibit inhibitors initial inoculation involved isolated kinase Lancet leukaemia lung magic bullets major microorganisms mode of action molecules mould mustard natural product normal OCH3 OH OH OH organisms pandemic patients penicillin pharmaceutical population potent prostate protein biosynthesis proteins receptor replication resistant response Salvarsan samples side-chain smallpox SMOKE BALL strains Streptomyces structure studies subsequent sulfonamides surgeon synthesis synthetic taxol therapy tion toxic treated treatment tumour vaccination vinblastine viral virus viruses ОН
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